THe following
anti-HIV drugs are known to cause
“lACTIC
ACIDOSIS”
Mitochondria are responsible
for creating more than 90% of the energy needed by the body to sustain life and
support growth.
Lactic
Acidosis
results when mitochondria are poisoned by anti-HIV drugs. As this occurs, mitochondria generate less and
less energy within the cell. Cell injury and even cell death follow. If this process is repeated throughout the
body, whole systems begin to fail and the health of the person who takes these
drugs is severely compromised by the acquired
(drug-induced) immune deficiency syndrome (AIDS).
LACTIC ACIDOSIS, HEPATOMEGALY, WITH OR WITHOUT STEATOSIS, ARE AMONG THE MOST SERIOUS TOXICITIES CAUSED BY ANTI-HIV DRUG POISONING MITOCHRONDRIA.
Lactic
Acidosis
appears to cause the most damage to cells of the brain, heart, liver, skeletal
muscles, kidney and the endocrine and respiratory systems. Depending on which cells are affected,
symptoms may include loss of motor
control, muscle weakness and pain, gastro-intestinal disorders and swallowing
difficulties, poor growth, cardiac disease, liver disease, diabetes,
respiratory complications, seizures, visual/hearing problems, lactic acidosis,
developmental delays and susceptibility to infection.
Hepatomegaly
Steatosis
Black
Box Warning Label
