THe following
anti-HIV drugs are known to cause
“FAT
REDISTRIBUTION”
THe following
anti-HIV drugs are known to cause
“FAT
REDISTRIBUTION”
Fat redistribution is one of a
growing number of adverse drug reactions (ADR) caused by
HIV drugs.
Anti-HIV drugs are toxic to cell mitochondria and cause diseases that affect all tissues and organs: mitochondrial myopathy, cardiomyopathy, neuropathy, lactic acidosis, pancreas failure, diabetes, liver failure and bone marrow failure.
Organ
manifestations of mitochondrial toxicity.
The question
marks
signify manifestations being debated as of 2007.
A bewildering
diversity of diseases caused by mitochondrial toxicity
appear
in the black box warning labels of the anti-HIV drugs
|
Disorder |
Manifestations |
|
Neurological
Neuromuscular
Heart
Endocrine
Gastrointestinal
Kidney
Blood
Psychiatric
General
|
Peripheral neuropathy, encephalopathy, dementia, seizures, stroke
Muscle weakness, exercise intolerance
Weak heart, conduction disorders
Diabetes mellitus
Colonic pseudo-obstruction, exocrine pancreas dysfunction, pancreatitis, hepatomegaly, steatosis, liver failure, lactic acidosis
Non-selective proximal tubular dysfunction with acidic blood, phosphaturia and glucosuria, glomerulopathy
Anemia, thrombocytopenia, pancytopenia
Depression
Multiple systemic lipomas, fatigue
|
Fat redistribution ranges from 30-50% of those taking anti-HIV drugs and increases with duration of drug use. The most prominent clinical sign is the so-called buffalo hump accompanied by a loss of subcutaneous fat in the face, limbs, and buttocks. There is an initial increase in limb fat during the first months of drug use, followed by a progressive decline over the ensuing years.
